This report summarizes data trends related to overdose, substance use, harm prevention, and related metrics. It also provides recommendations to inform programs developed by the Quinnipiack Valley Health District (QVHD) and New Haven Health Department’s (NHHD) joint effort to reduce overdoses through the Overdose Data to Action (OD2A) grant administered through the Connecticut Department of Public Health (CTDPH) via the Centers for Disease Control and Prevention (CDC). This report was compiled between March and June, 2021, using the latest available data.